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    Cisco Secure Email Threat Defense

    Cisco delivers the critical infrastructure to help organizations thrive in the AI era. By fusing networking, security, observability, and collaboration, we power how people and technology work together.

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    Email SecurityIntegrated Cloud Email Security (ICES)BEC ProtectionCloud Email Security

    Picari insights

    Enterprise organizations running Microsoft 365 that require advanced, API-based detection for evasive phishing, BEC, and internal email threats backed by Cisco Talos intelligence.

    Best for
    • Augmenting native Microsoft 365 email protections via API
    • Enterprises leveraging the broader Cisco security architecture
    • Detecting sophisticated BEC and identity deception attacks
    May not be ideal if
    • Organizations using Google Workspace or on-premises Exchange
    • Small businesses seeking an all-in-one, budget-friendly basic spam filter
    • Security teams seeking a standalone secure email gateway (SEG) with MX-record routing
    Next Step
    Considering Cisco Secure Email Threat Defense?

    Ask about pricing, alternatives, or if Cisco Secure Email Threat Defense is right for you.

    • Personalized fit analysis
    • See relevant alternatives
    • Run an evaluation when you're ready

    Core capabilities

    Advanced phishing and BEC detection
    Combats phishing and Business Email Compromise using sender authentication, machine learning, and AI engines that model local identity and real-time behavior to block identity deception threats[1][3].
    API-driven threat remediation
    Leverages Microsoft Graph API for fast detection and automated or manual remediation of malicious messages directly from Microsoft 365 mailboxes without changing mail flow[1][3].
    Cisco Talos threat intelligence integration
    Detects and blocks advanced threats like ransomware and QR codes using superior threat intelligence from Cisco Talos, one of the largest threat research teams[1][2].
    Complete email visibility including internal messages
    Provides full visibility into inbound, outbound, and internal user-to-user messages within Microsoft 365 mailboxes using conversation views and message trajectory for contextual threat analysis[1][2].

    Common use cases

    01

    Compliance-focused email security

    02

    Email threat prevention for knowledge workers

    03

    Microsoft 365 environment protection

    Things to consider

    Every product has trade-offs, and which of them matter depends on your environment, your team and your timeline.

    Ask Picari about Cisco Secure Email Threat Defense

    Security & compliance

    Frameworks Cisco Secure Email Threat Defense reports for security, privacy, and regulatory compliance.

    FedRAMP

    US federal cloud authorization

    Publicly available

    Cisco Secure Email Threat Defense pricing and integrations

    For Cisco Secure Email Threat Defense integration and pricing details, ask Picari. Start a briefing with your question, such as whether it connects to your SIEM, identity provider and ticketing stack, or how it is priced at your seat count and data volume.

    Ask Picari about Cisco Secure Email Threat Defense pricingAsk Picari about Cisco Secure Email Threat Defense integrations

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    Profile last updated on 9 October 2026 by Picari.