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    CalypsoAI (F5)

    AI Runtime & Agent SecurityLLM runtimeagentic security

    CalypsoAI, acquired by F5 in 2025 and rebranded as F5 AI Guardrails (formerly Inference Defend), delivers runtime security for AI models, agents, and applications. It combines agentic red-teaming with swarms generating 10,000+ new attack prompts monthly and real-time inference-layer protection against prompt injection, jailbreaks, data exfiltration, and denial-of-service. The platform includes the CalypsoAI Security Index and Agentic Warfare Resilience leaderboards for model benchmarking, plus policy enforcement for GDPR, HIPAA, and EU AI Act compliance. Best for enterprises deploying production AI copilots, RAG apps, and autonomous agents needing continuous vulnerability testing and defense integrated with F5 ADSP.

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    The Picari read

    CalypsoAI, now within F5, secures AI at inference time by inspecting prompts, tool use, and outputs to block injection, jailbreak, and data-leakage attempts. Its main differentiator is the combination of automated red teaming and runtime guardrails for deployed models and agents, aimed at enterprises running LLM apps across multiple clouds.

    • Enterprises deploying AI at scale who need strong security and compliance, especially those already utilizing F5 products.
    • Securing AI copilots in production
    • Protecting RAG applications from prompt injection
    • Ensuring compliance for AI model outputs
    • Vulnerability testing autonomous AI agents

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    CalypsoAI (F5) pricing and integrations

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    Profile last updated on 7 September 2026 by Picari.